Determinants of death from malformations of the circulatory system

Abstract Background Congenital malformations (CMs) were the second cause of death in infants under age 1 year North America and Europe 2017, behind perinatal causes.Of CMs, those circulatory system (MCSs) most lethal. Studies Brazil, England have reported higher mortality from MCS presence prematurity, non-white skin color newborn, asphyxia, low birthweigth, advanced maternal age, education level. The magnitudes associations vary. Those studies investigated neither risk MCS, with control mediation provoked by other variables, nor construction a model to explain relationship between variables deaths. Objective To assess geographic socioeconomic factors, as well gestational birth deaths MCSs first life Brazil 2006 2016, build an explanatory death. Methods Study Brazilian databases Information System on Live Births Mortality System, which linked deterministic submitted cohort strategy. Crude controlled relative risks estimated. Acyclic graphs directed creation models fetal all causes. Results linkage 32,011,727 live certificates 266,215 yielded 248,027 pairs. Low weight (RR=14.38), asphyxia (RR=5.95) fifth minute (RR=11.86), ≥35 years (RR=1.66), male sex (RR=1.13), residing West-Central (RR=1.22) small number prenatal visits (RR=2.24) increased MCSs. Prematurity multiple-gestation pregnancy had effects mediated regardless Maternal level did not increase but influenced Conclusion relation socioeconomic, factors 2016 showed that visits, sex, minutes are direct effect Deaths regions pose death, this was evidenced for causes Better care adequate would enable early diagnosis proper support treatment. Funding Acknowledgement Type funding sources: Public Institution(s). Main source(s): Federal University Rio de Janeiro